Born in Barbados and raised in the Cayman Islands, Kyffin Simpson competes for Chip Ganassi Racing.

He demonstrated his talent early on by winning the 2021 Formula Regional Americas Championship. Subsequently, he built a stellar record in the IMSA WeatherTech SportsCar Championship, including a Petit Le Mans GTD Class victory in 2022 aboard the Acura NSX GT3 EVO22, followed by a European Le Mans Series LMP2 Class Championship in 2023.

After racing in INDY NXT by Firestone in 2023, he made the step up to the INDYCAR SERIES in 2024. He immediately showed high potential by recording the Fastest Lap in his St. Petersburg debut and leading multiple laps in his first INDY500 start.

In the 2025 season, he achieved three Top-5 finishes and concluded the year 17th in the overall standings.